If you don't like those huge, cold and impersonal hotels,
Hotel San Francesco is your choice

 

Non Smoking |   Free WiFi |   Air Conditioning |   Airport Pick Up |   Rooftop Bar |   Bike Rental

 
The location is near trams and buses so very convenient and the Colosseum was an easy walk. Vatican walkable too.
Trastevere is very lively so it was good to be away from the main drag and have some quieter locals to drop in to.
Hotel modern, air conditioned and with a helpful staff.
Good breakfasts to start the day. Bed comfortable and a good shower.
— Dan, US